Heteroatom-containing chiral alcohols in general are involved in some interesting metal-catalyzed couplings. The use of biocatalysts to promote enantioselective oxidation of chiral alcohols is a promising metodology to achieve enantioenriched compounds. Herein, depending on the substrate either deracemization or enantioselective oxidation of silicon-, tin- and phosphorus-containing chiral alcohols were performed by Arthrobacter sp. whole cells. Some silicon-containing compounds were almost completely deracemized to their corresponding (R)-alcohols. Tin- and phosphorus-containing compounds were enantioselective oxidized, in which no enantioselective reduction of the produced ketones was evidenced so far. It is noteworthy that all the heteroatom-containing chiral alcohols were transformed by the Arthrobacter sp.whole cells, despite their size and/or chemical properties.

Deracemization and enantioselective oxidation of silicon-, tin- and phosphorus-containing chiral alcohols using whole cells of Arthrobacter sp. from Antarctica continent

248th National Meeting (2014)

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