Cyanohydrin is an important functionality that can be used as synthon for a variety of transformations in organic synthesis. Yet, lacking is a quick, efficient and non-empirical method for the absolute stereochemical determination of chiral cyanohydrins.Recently we have reported a biphenyl based porphyrin system as a host molecule for the determination of absolute stereochemistry of chiral monoamines using exciton coupled circular dichroism (ECCD). This poster will present application of this new porphyrin system as an ECCD-based reporter of chirality for cyanohydrins.

Determination of absolute configurations of cyanohydrins

248th National Meeting (2014)

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