Conotoxins are mini proteins that are isolated from venomous Conus snails. They have exhibited a role as ion channel inhibitors of high specificity. Therefore, they present an opportunity for use as potential therapeutic agents for various neurological ailments. The goal of this research is to establish a tunable chemical environment that will facilitate the consistent and reliable folding of disulfide rich peptides, including conotoxins, into their active conformations. Progress toward these endeavors will be presented.

Progress toward controlled disulfide formation to access neuroactive conotoxins

248th National Meeting (2014)

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