A serial of novel metformin analogs with symmetrical or unsymmetrical structures have been synthesized and screened for the inhibition of different cancer cell lines. Most of these analogs show more potent activity than metformin on the cell lines A-549, MCF-7, HCC-38, HCC-1806, and MDA-MB-231. Some of them have great drug-like potency for the treatment of breast cancer especially for triple negative breast cancer.

Synthesis and biological evaluation of metformin analogs for the treatment of cancer

248th National Meeting (2014)

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