Ethyl -1-14C-ethion and some of its degradation products have been prepared for the present investigation. Cotton plants were treated with 14C-ethion alone and in presence of deltamethrin and dimilin pesticides under conditions simulating local agricultural practice. 14C-residues in seeds were determined at harvest time; about 47.5 % of 14C-activity was associated with oil. After further seeds extraction, the ethanol soluble 14C-residues accounted for 10.6 % of the total seed residues, while the cake contained about 37.3 % of the total residues as bound residues in case of ethion only. The nonextractable residues (bound residues) decreases in presence of deltamethrin and dimilin pesticides and amounted to 8.1 % and 10.4 %, respectively. About 95 % of the 14C-activity in the crude oil could be eliminated by simulated commercial processes locally used for oil refining. Chromatographic analysis of crude cotton oil revealed the presence of ethion monooxon, O,O-diethyl phosphorothioate and O,O-diethyl phosphoric acid in addition to one unknown compound in case of ethion alone and ethion & dimilin. The same degradation products are found in case of ethion & deltamethrin besides ethion dioxon. While ethanol extract revealed the presence of ethion dioxon and O-ethyl phosphorothioate as free metabolites. Acid hydrolysis of the conjugated metabolites in the ethanol extract yielded O,O-diethyl S- hydroxymethyl phosphorodithioate. After feeding rats with the cake containing ethion bound residues, a substantial amount (60 %) of 14C-residues was eliminated in the urine, while the 14C-residues excreted in expired air and feces were 10 % and 9 %, respectively. About 11 % of the radioactive residues were distributed among various organs. The bound residue was quite readily bioavailable to the rats. Chromatographic analysis of urine extract was determined.

Fate of <sup>14</sup>C-ethion insecticide in presence of deltamethrin and dimilin pesticides in cotton seeds and oils, removal of its residues in oils, and bioavailability of its bound residues towards experimental animals

248th National Meeting (2014)

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Fate of 14C-ethion insecticide in presence of deltamethrin and dimilin pesticides in cotton seeds and oils, removal of its residues in oils, and bioavailability of its bound residues towards experimental animals

Fate of ¹⁴C-ethion insecticide in presence of deltamethrin and dimilin pesticides in cotton seeds and oils, removal of its residues in oils, and bioavailability of its bound residues towards experimental animals