Islet amyloid polypeptide (IAPP, Amylin) is responsible for islet amyloid formation in type 2 diabetes and contributes to the failure of islet cell transplants, however the mechanisms of IAPP-induced cytotoxicity are not known. Interactions with model anionic membranes are known to catalyze IAPP amyloid formation. Human IAPP damages anionic membranes, promoting vesicle leakage, but the features that control IAPP membrane interactions and the connection with cellular toxicity are not clear. Biophysical measurements in conjunction with cytotoxicity studies show that standard one and two component model systems do not capture the complexity of the <i>in vivo</i> environment.<br/>

Islet amyloid polypeptide: Membrane interactions and cytotoxicity

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.