There is some precedence to the idea that non-conventional metallodrugs can overcome the unwanted clinical side-effects produced by the widely used antitumoral drug cisplatin. In particular, trans geometry with different ligands has further proved that improved antitumoral action of simple molecules is not only possible but that this geometry can in fact activate their action in some particular cases. Recent studies have shown that the leaving group, iodido versus chlorido, in platinum complexes has a considerable influence on the reactivity versus specific biological targets. The complexes described here bear phosphine ligands, which has been hypothesized to increase cellular permeability due to increased hydrophobicity. Three novel trans-diiodophsophine platinum complexes were tested against five different human cancer cell lines to determine the IC50 for each complex and cisplatin. The dose that corresponded to the IC50 value was then applied to the cell lines and cell cycle analysis was performed. The latest results of these biological studies are presented.

Cytotoxicity and cell cycle studies of trans-diiodophosphine Pt (II) complexes

249th National Meeting (2015)

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