Amphiphilic copolymers, block or graft, have been extensively explored due to their ability to self-assemble in solution or in thin film giving rise to controlled nanostructured materials. The applications areas are multiple including nanomedicine and nanoelectronics.<br/>For both applications, the introduction of biosourced poly-/oligo-saccharides block is highly desirable in regards to their high hydrophilicity, chemical functionalities, biocompatibility, biodegradability and their relevant biological activities.<br/>In aqueous solution, «hybrid» amphiphilic oligosaccharide-based copolymers self-assemble into micellar aggregates or vesicles where the hydrophilic sugar blocks comprise the outer corona while the hydrophobic blocks are trapped inside through physical interactions. Recently, we have succeeded in preparing nano-organized thin films made from hybrid glycopolymers with size and domain spacing is approaching 10 nm while the today state-of-the-art is 20-30 nm. Such breakthrough innovation is favored by the rigid nature of the oligosaccharide and the strong incompatibility between the blocks. From a synthetic point of view, "hybrid" glycopolymers were obtained according to a three-step process consisting of: 1) preparation of scalable and size-homogeneous oligosaccharides from biosourced materials by enzymatic or chemical processes; 2) conjugation with “clickable” functions and 3) « click » coupling of pre-formed blocks referred as « grafting onto » method. The synthesis and self-assembly properties will be described.

Well-defined sugar-based amphiphilic copolymers: From controlled architectures to nanostructured materials

249th National Meeting (2015)

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