Concurrent tandem catalytic (CTC) methodologies have been developed for the hydrodehalogenation and the cyanation of aryl halides using a multifunctional copper catalyst.  New CTC methodologies are currently under development for C-N bond-forming reactions such as the amination and amidation of aryl halides.  The proposed CTC mechanism consists of an initial halide exchange step to form aryl iodides from less reactive aryl bromide and aryl chloride substrates.  As the aryl iodide intermediate is generated, it is consumed as the substrate in a subsequent C-H, C-C, or C-N bond-forming reaction.  Optimized conditions and substrate scope for these reactions, along with evidence that these reactions are occurring via a CTC mechanism, will be presented.<br/>

Microwave-assisted copper-catalyzed reactions of aryl halides via concurrent tandem catalysis

249th National Meeting (2015)

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