Mixed-metal complexes have been prepared and studied with a number of sub-units to provide for multifunctional supramolecules with multiple means of interactions with biomolecules. Sub-units are used as targets (TAR), delivery vehicles (DEL), light absorbers (LA), luminescent reporters (LUM) bridging ligands (BL), thermally activated bioactive sites (TAB), and photochemical activated bioactive sites (PAB). LA employed are Ru and Os polyazine MLCT absorbers, BL are bis(diimine) ligands capable for connecting two metal centers together. TAB centers are cis-PtCl2 units that bind to DNA thermally similar to cisplatin. PAB are of two types, oxygen dependent (MLCT ROS generators) and oxygen independent (cis-RhCl2). The expansion of the structural diversity of these supramolecules has led to the development of systems with complex interactions with biomolecules. Recent studies have shown a PAB(LA)-BL-TAB molecule to be active as a light activated drug to kill rat malignant glioma F98 cells. LUM-LA(PAB)-BL systems have been developed as initial test systems to study metal complex uptake and cellular distribution via confocal microscopy with oxygen dependent phototoxcity. LA-BL-PAB systems have been prepared that allow for light activation with red light to lead to photomodification of DNA through the PAB site. Other motifs will be described and relating structure and function. The authors thank the NSF CHE-1301131 and VT ICTAS for generous support of this work.

Multifunctional supramolecules for interactions with DNA and cancer cells exploiting photohemical activation

249th National Meeting (2015)

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