<b>Scaffolds play a fundamental role in delivering the warhead to the target cysteine (Cys 797) in the development of irreversible EGFR T790M inhibitors. Stereoelectronic effects are therefore paramount in the design of these scaffolds to optimize this interaction. Synthesis of unique scaffolds and their utilization towards irreversible 7H-pyrrolo[2,3-d]pyrimidine</b> <b>EGFR T790M inhibitors is described herein.</b>

Synthesis of warhead containing scaffolds on irreversible 7H-pyrrolo[2,3-d]pyrimidine EGFR T790M inhibitors

249th National Meeting (2015)

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