New methods for drugs detections are necessary to improve the time and sensitivity for drug testing. Our work is focused in the development of a strategy to produce bimetallic silver-gold core-shell nanoparticles for the study of drugs interactions. Formation of the nanoparticles was achieved by the reduction of the AgNO3 with NaBH4 and HAuCl4 with sodium citrate and polyethylene glycol. A conventional microwave was applied to complete the synthesis. This technology offers minimization of reaction times and stabilization of nanoparticles. In this research, we explore the interactions with Penicillin, Ciprofloxacin, Vancomycin and Clindamycin with the silver-gold core shell nanoparticles. Characterization of the nanoparticles was performed using UV-Vis absorption spectroscopy with a band absorption center at 523 nm, Diffracted Light Scattering (DLS) study shows a mean diameter of 75 nm. Interaction with antibiotics results in a red shift between 15-70 nm. Also a change in color is produced with the addition of the antibiotics to the bimetallic nanoparticles.

Functionalization and characterization of bimetallic silver-gold nanoparticles with antibiotics

249th National Meeting (2015)

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