ApAFP752 is an 8.9-kDa hyperactive antifreeze protein found in the desert beetle <i>Anatolica polita</i>. Antifreeze proteins are an evolutionary response that contributes to the freeze resistance of certain fish, insects, bacteria, and plants. These proteins adsorb to the ice crystal surface and restrict growth within a certain temperature range, but the exact mechanism of growth inhibition is still not fully understood. ApAFP752 is proposed to have a β-helical secondary structure with a flat ice-binding surface. We are presenting the structural-functional characterization of ApAFP752 by nuclear magnetic resonance (NMR) spectroscopy and <i>in vivo</i> studies.

Structural and functional characterization of the antifreeze protein ApAFP752

249th National Meeting (2015)

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