With the increasing use of nanoparticles in both science and industry, their chemical modification became a significant part of nanotechnology. We've explored several applications of nanoparticles that will benefit from the controlled surface functionalization: dentifrices and filling materials, drug delivery, improvement of bone implants and sunscreens. Functionalization of titanium dioxide and silica nanoparticles improves their adhesion to human dentin, which opens their future use for treating tooth hypersensitivity by occlusion of dentin tubules and carriers of remineralizing and other active components. Functionalization of carbon nanofibers helps control their alignment for enforcement of mechanical strength of dental fillings. Functionalization of titanium dioxide improves adhesion between titanium dioxide nanotube-coated implants and bones and imparting antibacterial properties. The relationship between morphology of nanoparticles and their affinity to organic molecules (salicylic and caffeic acid) using multiple adsorption isotherms, and toward material surfaces using TEM-imaging, let us suppress photodegradation of caffeic acid in the presence of titanium dioxide and work toward new formulations of sunscreens, containing both components. The developed reliable quantitative procedures for photometric determination of primary and secondary surface amino-groups was employed for characterization of the synthesized new materials.

Exploring biomedical applications of nanoparticles by their surface functionalization

249th National Meeting (2015)

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