The thiourea, N-(2-hydroxyethyl)-N’-phenylthiourea, can be synthesized at high yield and has demonstrated reaction condition-dependent cyclization to selectively form an oxazole or thiazole. This selective cyclization shows great promise as a synthetic tool due to its ability to create two synthetically useful ring structures from a common parent compound. We will discuss optimal conditions for selective cyclization of N-(2-hydroxyethyl)-N’-phenylthiourea as a means for selectively synthesizing oxazole and thiazole ring structures from a common intermediate.

Selective oxazole and thiazole formation from a common intermediate

249th National Meeting (2015)

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