Pyrrolizidine alkaloids (PA) are potentially toxic naturally occurring secondary products, found in the plant family Asteraceae. As a member of the family, Arnoglossum is expected to contain PA's. Examination of the GC-MS data has shown that the major alkaloids in this species are otonecine based seco-PA’s, including otonecine, florosenine, floridanine, and floricaline. It was difficult to quantify the amount of florosenine due to its co-elution with floridanine. A second compound, also at m/z 441 was observed and trivially named arnoglossine, this compound appears to be isomeric to floridanine. We will focus on chromatographic isolation and structural elucidation of minor Arnoglossum PA’s using NMR analysis.

Structural elucidation of pyrrolizidine alkaloids from Arnoglossum plantagineum

249th National Meeting (2015)

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