Although several strategies exist that allow researchers access to chiral aziridines, one method that remains largely unexplored is the stereoselective reduction of prochiral 2H-azirines. This body of research is focused on the development and optimization of a catalytic asymmetric 2H-azirine reduction method that employs non-racemically ligated copper hydride. The synthetic route used to generate 2H-azirine starting materials, and the methods explored for derivatization and resolution of chiral aziridine products will be reported along with the reaction development and optimization.

Developing a copper-catalyzed asymmetric reduction of 2H-azirines

249th National Meeting (2015)

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