Glutathione-coated luminescent gold nanoparticles (GS-AuNPs) of ~2 nm are known for their high resistance to serum protein adsorption. Our studies illustrate that these GS-AuNPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs), in addition to rendering the NPs the fluorescence property. After the integration of GS-AuNPs onto the surface of SPIONs to form the hybrid nanostructures, these hybrid nanoparticles’ protein adsorption was about 10-fold lower than those of the pure glutathione-coated SPIONs suggesting that GS-AuNPs are capable of providing a stealth effect against serum proteins.

Glutathione-coated luminescent gold nanoparticles: A surface ligand for minimizing serum protein adsorption

249th National Meeting (2015)

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