Sodium halides were found to inhibit the copper-catalyzed azide-alkyne cycloaddition (CuAAC) in a model system. This presentation discusses the basis for this inhibition and experimental precautions that can be taken to enable the CuAAC when halides are present. Specifically, silver salts and various ligands can be used to outcompete the inhibitive binding of halides to the copper catalyst.

Copper-catalyzed triazole synthesis in the presence of halides

249th National Meeting (2015)

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