Conjugation of proteins to cellulose nanofibrils (CNF) and bacterial nanocellulose (BNC) was employed to demonstrate the possibility for using cellulose as a platform for diagnostic assays and biofiltration. Both physical and covalent attachment of proteins were applied. Pre-adsorbed carboxymethyl cellulose (CMC) provided the electrostatic counterpart to attach the given proteins. In addition, the carboxyl groups of CMC were utilized for the covalent conjugation of proteins. As prepared cellulose substrates were then applied as biointerfaces for detection of various proteins. The bioseparation of human serum albumin was demonstrated by using BNC tubes. Main results and possible applications for such systems will be discussed.<br/>

Preparation of nanocellulosic biointerfaces

249th National Meeting (2015)

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