Small molecule modulators have recently been recognized for their clinical potential for diverse cancers. This, combined with their use as tools to study the importance of splice-regulated events and their association with disease, continues to fuel to the discovery of new splice modulators. One of the key issues with the current class of materials arises in stability. While fast acting, many of the contemporary probes undergo rapid metabolic degradation, which can lead to unwanted responses and activities. We describe the preparation of bench stable splice modulators by adapting new scaffold motifs.

New splice modulators targeting the human spliceosome

251st National Meeting (2016)

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