Our group recently reported a family of bis-phenolic receptors with ammonium groups (Fig: 1) that bind to phosphotidylglycerol (PG), a lipid found in high concentration in bacterial cytoplasmic membranes. We now report on the elaboration of these receptors with multi-functional groups to align correctly via hydrogen-bonding to both the phosphate anion portion and glycerol hydroxyls of PG (Fig:2). The anion-receptor binding stoichiometry and K<sub>a</sub> will be determined by <sup>1</sup>H NMR (Job plots and titrations) and the associated enthalpy and entropy of binding will be measured with ITC. These multifunctional receptors are intended to be component parts of new antibiotics that inhibit bacterial growth.

Preparation and characterization of ammonium receptors that target bacterial membranes

251st National Meeting (2016)

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