Polysaccharide polymers, due to their functional, renewable, nontoxic and biodegradable properties, have diverse applications in medical and pharmaceutical technology. Physiochemical aspects of these polymers, which influence their biomedical functionality, are often related to their source and production process. In addition to average molecular weight and chemical structure, crystallinity, particle size and morphology also determine the biomedical characteristics. This study presents the influence of these factors on biological processes (e.g. hemostasis efficacy) as well as the synthesis and characterization of said polysaccharide hydrocolloid scaffolds, stabilized by electrostatic and steric interactions. Particle size, molecular weight, surface charge, and rheological behavior are studied to understand microstructure of this hydrocolloidal system and factors influencing stability and quality of formulation and its biomedical efficacy. Internal (e.g. structure, purity), environmental, and process factors (e.g. method of sterilization) are shown to have critical impacts on long-term stability of polysaccharide-based products. These impacts are identified and described in detail within the study. The novel polysaccharide hydrocolloid scaffold in this study is shown to have the ability to mimic the body’s extracellular matrix and accelerates hemostasis both in vitro and in vivo.

Development of novel polysaccharide hydrocolloid composite: Influence of physicochemical properties on biochemical activity

251st National Meeting (2016)

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