<br/>Using computational analysis of reaction energetics, we predicted a mild, efficient, and practical means of accessing borylated pyridines, imidazoles, and other N-heterocyclic compounds via a C-H activation approach. Experimental results confirmed these computational predictions. We built upon these findings to develop a methodology employing Lewis acids additives, which not only activate the substrates for reaction but also determine the fate of the products obtained.

Room temperature borylation of N-heterocycles using a Lewis acid effect

251st National Meeting (2016)

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