Development of an efficient, step-economical and library amenable approach for the synthesis of bi- and tricyclic phosphorus heterocyles is reported. Phosphorus heterocycles have been shown to impart a wide variety of biological activities leading them to serve as novel pharmaceutical agents and biological probes. The key reactions involved in the synthesis of these small molecules include one-pot sequential, enyne ring-closing metathesis and Diels-Alder reaction (ERCM/DA). This step-economical protocol enables access to structurally and stereochemically diverse bi- and tricyclic phosphate and phosphoramidate analogs in fewer number of steps from easily accessible precursors.

One-pot, sequential enyne ring-closing metathesis/Diels-Alder protocol for the synthesis of bi- and tricyclic phosphorus heterocyclic compounds

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.