Nanoparticles have attracted enormous interest in biosensing related to a range of unique properties they possess. Here we will present our findings on using gold coated magnetic nanoparticles as dispersible electrodes that can be sent out into the sample, collect the analyte and bring it back to an macroelectrode for detection. This strategy is shown to give highly sensitive sensors that have much faster response times than classical macroscopic sensors. Here how the particles are made [1] is discussed followed by how they perform as electrodes before demonstrating their surface modification strategies to convert these nanoparticles into selective nanoelectrodes for sensing [2]. Application of these dispersible nanoelectrodes are demonstrated for the sensing of metal ions [3], proteins such as prostrate specific antigen and small organic molecules such as the antibiotic enrofloxacin. These three examples all demonstrates different transducing formats in which these dispersible electrodes can be employed, from straight amperometric detection, to labelling approaches and finally employing these particles in biochemresistors [4]. In our most recent work we have demonstrated how this concept can be used for the detection of nucleic acids, for multiplex sensing and to make calibration free devices. Acknowledgements We would like to thank the Australian Research Council and the University of New South Wales for funding this research References 1. I. Goon, L. Lai, M. Lim, P. Munroe, J.J. Gooding and R. Amal, Chem. Mater. 21, 673-681 (2009). 2. I. Goon, L.M.H. Lai, M. Lim, R. Amal and J.J. Gooding, Chem. Comm. 46, 8821-8823 (2010). 3. L.M. H. Lai, I.Y Goon, M. Lim, D.B. Hibbert, R. Amal and J.J. Gooding, J. Electroanal. Chem. 656 130-135 (2011). 4. L.M.H. Lai, I.Y. Goon, K. Chuah, M. Lim, F. Braet, R. Amal, J.J. Gooding, Angew. Chem. Int. Ed. 51 6456-6459 (2012).

Magnetic nanoparticles as dispersible electrodes

251st National Meeting (2016)

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