The FABP2 gene (3.4 kb size) is located at chromosome 4q28–31 and has 4 exons (700 bp) and 3 introns (2,650 bp). The substitution of alanine to threonine (Ala54Thr), resulting from the conversion of a guanine to an adenine, is related to insulin resistance and obesity. In this study, we investigated the relationship between the FABP2 Ala54Thr polymorphism and obesity, hemodynamic variables, blood lipid profile, and insulin resistance in middle-aged Korean women with abdominal obesity. This study included 243 middle-aged Korean women with abdominal obesity from Gyeonggi province, South Korea who received no medication. FABP2 Ala54Thr polymorphism was analyzed by PCR-RFLP, and obesity indices, hemodynamic variables, blood lipid profiles, and insulin resistance were analyzed. After analyzing the FABP2 Ala54Thr genotype for 243 subjects, 117 had the AA homozygotic genotype, 100 had the AT heterozygotic genotype, and 26 had the TT homozygotic genotype. AT heterozygotic individuals exhibited a significantly higher waist-to-hip ratio (WHR), abdominal fat area, and visceral fat area, and TT homozygotic individuals displayed higher triglyceride and fasting glucose levels. The results of this study showed that the FABP2 Ala54Thr mutation increases the risk of central obesity and obesity-related metabolic syndrome in Korean middle-aged women.

Effect of fatty acid binding protein 2 Ala54Thr gene polymorphism on obesity and metabolic syndrome in Korean middle-aged women

251st National Meeting (2016)

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