Proteins and metals play key roles in infection and disease progression. The design and synthesis of peptide based inhibitors and metal chelators offer potential alternative methods for disease treatment. Our research focuses on the synthesis of peptide linked metal chelators for the disruption of the aggregation of amyloid β, the key peptide in the formation of the characteristic neurodegenerative plaque in Alzheimer’s disease. In addition, the peptide chelator complexes are designed to remove toxic metal ions associated with the aggregates (including Zn2+, Cu2+, and Fe3+). Assembly of the chelator complex begins with the synthesis of an ethylenediamine backbone and the ligand-binding domain. Subsequently, the two synthetic fragments are combined and linked to biologically relevant disruption peptides to form the final peptide chelator complexes. These peptide chelator complexes provide the framework for derivatized peptide-complex synthesis in the future.

Synthesis of peptide-linked metal chelators: Molecular disruptors for amyloid-β aggregation

251st National Meeting (2016)

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