The direct N-alkylation of hydroxypyridine is being explored. Catalyzed by Pd2dba3, the N-allylated 2-pyridone product was synthesized using allyl methyl carbonate and hydroxypyridine. The N-alkylation of assorted allylic carbonates will be further investigated.

Reaction development of Pd-catalyzed synthesis of substituted 2-pyridones

251st National Meeting (2016)

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