We present a novel class of thiol-protective groups for cysteines. The thiosulfonyl based protective group provides stability against hard nucleophiles, e.g. amines, while promoting reactivity towards thiols. These properties lead to a protective group, which is stable during peptide synthesis but can be selectively addressed by thiols leading to disulfide formation.

Novel protecting and activating group for reactive cysteines

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.