Despite the many reports of using novel colloidal particles in to modulate the immune system to treat or prevent diseases, there is still a large gap in their translation to the clinic. Some of the main reasons for this is the difficulty for many said systems to be manufactured reliably and in large enough scale. We will present our results on the development of a new family of colloidal particles we term supramolecular hacky sacks (SHS) that are readily made from the self-assembly of guanosine derivatives (8ArGs). We will present the synthesis and characterization of a small library of these SHS particles and will show that they are suitable for the encapsulation and cellular delivery of a number of biologically active molecules including anti-cancer drugs, polysaccharides, DNA and proteins. Furthermore, we will show results that indicate that the SHS have very promising in vitro and in vivo activity as immunomodulators, as well as vaccine adjuvants and delivery agents. We will discuss how some of these SHS particles could overcome the translational gap because of the following features: (a) small-molecule based technology; (b) easily customizable and suitable for structural activity relationships (SAR) studies; (c) the most promising 8ArGs could be readily scaled up to perform further development aimed a clinical applications.

Immunomodulatory activity of colloidal supramolecular particles made from guanosine derivatives

251st National Meeting (2016)

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