Carbonic anhydrase (CA) is being used as a model for matrix metalloproteinases (MMPs). CA is a more ubiquitous protein that binds zinc in the same manner as MMPs, in a tri-histidine manner. Potential pharmaceutical building blocks are being evaluated using CA as a model due to this structural similarity in order to probe binding information.

Carbonic anhydrase: A model for matrix metalloproteinase inhibition

251st National Meeting (2016)

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