Aminoisobutyric acid(AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB’s carboxylic acid using conventional amidation protocols is often problematic. We discovered that a transamidation protocol utilizing methyl Boc-aminoisobutyrate and magnesium amidates of various reactivities produces the corresponding amide derivatives in good to excellent yields.

Development of a novel amide coupling strategy for aminoisobutyric acid using magnesium amidate

251st National Meeting (2016)

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