Synthesis of BRL-37959 has previously been reported. As a NSAID, the compound was tested for, and found that it had, very low gastric irritancy. We have developed a short and more cost effective procedure for the synthesis of BRL-37959. The old method was tedious and had very low yields (≤ 5%). Our developed method is simple and uses inexpensive starting material, as well as giving high overall yields (up to 89%). Moreover, in molecular modeling (docking)studies it has been found that the compound selectively binds with COX-2 enzyme. But, in enzyme screening we have found that BRL-37959 is selective to COX-1 enzyme.

Synthesis and biological evaluation of benzofuran ring containing compound BRL-37959 and its analogs

251st National Meeting (2016)

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