Abnormal creatinine levels are key indicators of disease and important guides when choosing a medication strategy and the dosing of that strategy. Monitoring creatinine levels in biological fluids is an extremely important and common practice in healthcare worldwide. That said, current methods for creatinine quantification present significant drawbacks when aiming to combine accuracy, simplicity and affordability. I will introduce an unprecedented synthetic receptor, a mono-phosphonato aryl-extended calix[4]pyrrole, displaying remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guests in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore, playing <i>the</i> key role in a highly sensitive and selective potentiometric sensor.

Recognition and sensing of creatinine using phosphonato aryl-extended calix[4]pyrroles

251st National Meeting (2016)

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