Multivalency is a ubiquitous phenomenon in nature involving complex binding mechanisms for achieving non-covalent strong yet reversible interactions. Interfacial multivalent interactions at pathogen-cell interfaces (left) can be competitively inhibited by multivalent scaffolds (right) that prevent pathogen adhesion to the cells during the initial stages of infection, while monovalent inhibition fails to inhibit the biological pathway (middle). The lack in understanding of complex biological systems makes the design of an efficient multivalent inhibitor a toilsome task and is the reason why as of yet no multivalent anti-infective has emerged on the market until now. This talk will focus on the design and application of multivalent nanosystems as potent inhibitors for pathogens.<br/>

Multivalent 1D, 2D and 3D polymers as potent inhibitors for pathogens

252nd National Meeting (2016)

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