Bacterial infection has been a serious problem in the field of biomaterial. One of the most suitable ways to solve biomaterial-associated infection is preparing antibacterial films on biomaterials. In this work, we chose polyhydroxybutyrate (PHB) as the substrate to prepare biodegradable materials with superior bactericidal activity. Several N-halamine compounds were designed and synthesized, and introduced into PHB to generate antimicrobial nanofibrous membranes by physical mixture or grafting polymerization. The N-halamine compounds were determined by NMR and FTIR. The obtained nanofibrous membranes were characterized by SEM, TG, and XPS. Upon the chlorination treatment of household bleach, the nanofibrous membranes provided potent antibacterial activities by inactivating both <i>S. aureus</i> (ATCC 6538) and <i>E. coli</i> O157:H7 (ATCC 43895) within short contact time. Meanwhile, cytocompatibility of the samples was also evaluated with rat skin fibroblasts using XTT assay. It is believed that our designed antimicrobial nanofibrous membranes based on PHB and N-halamine have great potential for food packaging and biomedical utilizations.

Preparation and characterization of antimicrobial fibrous membranes based on polyhydroxybutyrate

253rd National Meeting (2017)

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