We have previously described a shape memory polymer (SMP) scaffold having the capacity to conformally “self-fit” into irregular bone defects and improve healing. This scaffold was based on poly(ε-caprolactone-DA) (PCL-DA) whose shape may be actuated by a transition temperature have shown utility for a variety of biomedical applications. Important to their utility is the ability to modulate mechanical and degradation properties. Thus, in this work, SMPs are formed as semi-interpenetrating networks (semi-IPNs) comprised of a cross-linked PCL diacrylate (PCL-DA) network and thermoplastic poly(L-lactic acid) (PLLA). The semi-IPN uniquely allows for requisite crystallization of both PCL and PLLA. The influence of PLLA (PCL:PLLA weight % ratio) and PCL-DA molecular weight (n) on film properties are investigated. PCL-PLLA semi-IPNs are able to achieve enhanced mechanical properties and accelerated rates of degradation.

Self-fitting scaffolds based on PCL-PLLA semi-IPN Shape Memory Polymers (SMPs)

253rd National Meeting (2017)

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