The icosahedral cluster B12H122– and its derivatives have seen potential use in applications as varied as pollution remediation and cancer therapies. Their high stabilities, electronic properties and low toxicities make them ideal substrates for these fields. Our interest in the high-yield production of substituted dodecaborates led us to investigate the ruthenium-catalyzed substitution of B12H122– utilizing microwave heating. The reactions of B12H122– with THF or C6H5Cl provided the substituted clusters B12H12-nRn2– (R=OBu, n=1,2; R=C6H4Cl, n=1-3) upon purification by column chromatography. Products were characterized by 11B, 1H and 13C NMR spectromentry, and ESI-MS. Implications regarding the regiochemistry of the substitutions will be discussed.

Ruthenium-catalyzed subtitutions of icosahedral dodecaborates

253rd National Meeting (2017)

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