G4-quadrupli appear in the telomeric regions of DNA and are responsible for maintaining the structural integrity of the genome. Past studies indicate that it is possible for large planar molecules to intercalate G4-DNA and ultimately trigger cellular apoptosis. Because of this, G4-DNA has been the center of many novel anti-cancer strategies revolving around large planar molecules.<br/>Phosphonium salts have been known to selectively target cancerous cells due to their lipophilicity and delocalized positive charge. We have incorporated the phosphonium salt moiety into previously established G4 binders such as transition metal complexes of 4′-(4-Methylphenyl)-2,2′:6′,2′′-terpyridine (ttpy) in order to enhance the cancerous cellular uptake properties of these molecules. Herein, we report the synthesis, characterization, and DNA binding properties of a variety of compounds exhibiting the [M]-ttpy-PR<sub>3</sub> motif.<br/>

Synthesis, characterization, and binding properties of metal-based G4 intercalators containing a phosphonium tether

253rd National Meeting (2017)

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