We have developed a concept of magnetic field-directed drug delivery system with two different populations of hybrid magnetic nanoparticles (MNPs). Each hybrid particle consists of an inorganic superparamagnetic core, however one is coated with the enzyme xylanase and the other with its substrate, a linear polysaccharide of xylan. These particles are responsive to an external magnetic field which when activated, aggregates the molecules together triggering the local biocatalysis of xylan degradation thus releasing the drug molecules at the site of interest. The set of hybrid particles consisting of a magnetic core coated with xylan is used to bind and protect the drug molecule while the second set of MNPs were coated with an amino functionalized silica layer which has the ability to immobilize a specially prepared xylanase-copolymer conjugate exhibiting improved biocatalytic efficiency as well as improved structural stability. The two sets of MNPs in colloidal suspensions were triggered with an external magnetic field to aggregate together and the biocatalysis of xylan degradation was monitored successfully using fluorescence spectroscopy.

Magnetic field triggered degradation of xylan with a xylanase-copolymer conjugate for controlled drug delivery

253rd National Meeting (2017)

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