The goal of drug delivery system is to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable.  The major advantages of implantable systems includes local delivery of drugs at a constant rate, fewer drugs required to treat the disease state, minimization of probable side effects, and better efficacy of treatment while administering unstable drugs once a week to once a year that in the past required frequent daily dosing. There are few demonstrated and approved material options available to modulate consistent drug delivery profile over time. The silicones are versatile as 5 % to 50% of the active agent can be incorporated in the silicone based device to release between micrograms to milligram of drug release per day. The drug release can be modulated by using proper silicone and drug release additive along with the active ingredient. Despite the ability to form hydrogen bonds, silicone is considered hydrophobic due to methyl groups on the siloxane polymer .The silicones are well suited for active agents having non-polar structure with alcohol or ketone structure. This presentation will discuss silicon chemistry, and silicone compatibility, potential interactions, and release properties.  <br/>

Optimizing drug release using silicone based implantable drug delivery systems

253rd National Meeting (2017)

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