Zika virus is primarily transmitted by Aedes mosquitoes, primarily Aedes aegypti. As part of joint efforts between the USDA and the DWFP (Deployed War Fighter Protection) program of the DoD, natural products and their synthetic analogs were investigated for mosquito control properties. From the culture filtrate of the plant pathogenic fungus Diaporthe eres, 3,4-dihydro-8-hydroxy-3,5-dimethylisocoumarin was isolated. The natural isocoumarin and its synthetic analogs were evaluated for mosquito larvicidal activity against two strains of mosquito larvae. The natural isocoumarin was marginally active as a larvicide, but the synthesized analogs were significantly more active as larvicides. Some of these analogs showed larvicidal activity against a permethrin resistant Puerto Rican strain of A. aegypti as well as the permethrin susceptible Orlando strain of A. aegypti. These compounds were not active as topical mosquito adulticides. Isolation, synthesis, and mosquito larvicidal activities of these isocoumarins will be discussed.

Mosquito larvicidal activity of some isocoumarins

253rd National Meeting (2017)

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