The need for new antimalarial drugs is greater than ever before owing largely to the emergence of multidrug resistance in common pathogens as well as the rapid emergence of new infections. Malaria is one of the most common infectious diseases which affect large populations, especially in less developed countries. Plasmodium is the parasitic protozoa that cause malaria. The life cycle of Plasmodium involves two hosts (mosquito and mammals). During the life cycle, gametocytes (mature sexual stage) are present in the blood of infected vertebrate hosts while gametogenesis (activation of mature gametocytes) and formation of diploid zygotes only occur in the midgut of vector mosquitoes. It has been reported that the process of gametogenesis is induced by various factors such as pH and temperature change. Xanthurenic acid, which is present in the head and midgut of the mosquito, also plays an important role in the differentiation of the parasite. Xanthurenic acid and a series of analogs have been synthesized and evaluated with the aim of impeding the transmission of malaria.

Synthesis and evaluation of xanthurenic acid analogs for impeding transmission of Plasmodium falciparum from host to vector

253rd National Meeting (2017)

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