Carbonic acid derivatives of dextran possessing furfuryl- and maleimido moieties were synthesized and processed into thin films by spin coating. First, products with different degrees of substitution (DS) of up to 3.0 and substitution patterns were obtained. Thin films possessing maleimide groups were obtained by spin coating of maleimido dextran (furan-protected) and dextran furfuryl carbamate that was converted with bismaleimide. The removal of the protecting group (furan) on the thin film was monitored by QCM-D and compared with gravimetric analysis of the bulk material. Thin films were obtained by spin coating and characterized by AFM, QCM-D, FTIR spectroscopy, and XPS. Surface morphology, hydrophobicity, swelling behavior, and reactivity of dextran furfuryl carbamate bismaleimide adducts are suitable for the preparation of surfaces containing cysteine. Up to 9 mgm<sup>-2</sup> of bovine serum albumin (BSA) are adsorbed on this nanorough, hydrophilized films at different pH values (4, 6, and 8.5). The BSA layer might resist nonspecific adsorption of biological molecules and could be interesting for prevention of biofilm formation on medical devices.

Reactive film-forming maleimido dextrans for cysteine-containing surfaces adsorbing BSA

253rd National Meeting (2017)

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