Titanium aluminum vanadium is a common implant material due to its corrosion-resistance, lightweight and biocompatibility. Bacterial colonization may occur upon or shortly after implantation, ultimately forming a biofilm. Biofilms are communities of sessile bacteria that adhere to surfaces possibly causing a difficult to treat infection, but preventative measures can be taken. Low concentrations of nitric oxide have been shown to disperse bacteria from biofilms. Modification of the implant to release nitric oxide has the potential to decrease biofilm formation in conjunction with antibiotics. N-diaziomdiolates (NONOates) release two moles of nitric oxide per molecule at physiological conditions. Self-assembled monolayers with a carboxylic tail group were used as linkers to immobilize diethylene triamine N-diaziomidiolate (DETA NONOate) using a carbodiimide reaction. Diffuse reflectance infrared Fourier transform spectroscopy (DRIFT) was used to characterize the monolayer and to confirm attachment. Attachment was confirmed by the presence of amide I and amide II stretches. The effectiveness of the NO released will be tested against S. Epi.

Towards a bacteria retardant implant surface

253rd National Meeting (2017)

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