Botulinum neurotoxins (BoNTs) are some of the deadliest naturally occurring toxins. BoNTs are produced by a common bacterium found in soil called <i>Clostridium botulinum </i>and are commonly prescribed medicinally for their ability to locally paralyze muscles at low doses. Based on previous research, a matrix of small molecules was created in order to investigate the effectiveness of certain features in inhibiting the activity of botulinum neurotoxin serotype A. Each molecule synthesized has a counterpart, or a series of counterparts, with slight structural variations. Biological assays will be used to measure the BoNT inhibition of these molecules and the structure-activity relationship will be further refined from the results.

Synthesis of small-molecule inhibitors of botulinum neurotoxin

253rd National Meeting (2017)

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