This investigation will involve the synthesis of polyamine analogs produced in 100% ethanol as the solvent.  These nucleophilic substitution reactions with alkyl halides will produce Bis (3-phenylpropyl), Bis (1-phenylmethyl), and Bis (4-phenylbutyl) polyamines. The Aryl halides used in these syntheses were, 1-bromo-3 phenyl propane, 1-bromo-1-phenyl methane, and 1-bromo-4-phenyl butane and the polyamines were putrescine and spermidine.  In this study 100% ethanol was used as the greener reaction solvent, which allowed for production of the polyamine analogs to proceed in a less toxic environment. Alcohols are preferred solvents as they are more environmentally friendly, can be reclaimed or recycled, and reactions are run at lower temperatures.  It was also found, in this work that the use of 100% ethanol increased the product yield dramatically when compared to the more toxic solvents used in previous studies in our laboratory. <br/><br/> <br/>

Synthesis of several polyamine analogs as possible growth inhibitors for breast cancer cells

253rd National Meeting (2017)

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