Previously we have reported the generation of β-fluoroamides from alkenes <i>via </i>electrophilic fluorinations with F-TEDA in dry acetonitrile. We now report improved yields in this reactioon using microwave assisted chemistry. The low to modest yields from thermal reactions were improved to at least 80% in a series of alkenes when the microwave approach was used. We continue to explore structural boundaries in these reactions as well as the conversion of the fluoroamides to biologically interesting β-fluoroamines.

Microwave synthesis of β-fluoroamides from alkenes

253rd National Meeting (2017)

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