The main requirement for green chemistry is alternative reaction media to replace heavy use of organic solvents in pharmaceutical industry. They are the basis of many of the cleaner chemical technologies that have reached commercial development. Many alternative solvents using water, supercritical carbon dioxide and supercritical water; room-temperature ionic liquids; biphasic systems; and solvent-free systems that utilize the surfaces or interiors of clays, zeolites, silica, and alumina are possible. Out of these water is the most economical and cheap. MCAT-53 TM is a proprietary recyclable ruthenium-containing catalyst for C–C coupling reactions in aqueous media. In contrast to Pd-catalyzed C-H activated and directing group (DG) directed C-C coupling reactions, MCAT-53TM achieves C–H-activated C–C coupling in water under ligand-free conditions, requiring no auxiliary oxidants (such as copper (II) salts and silver (I) salts, or benzoquinone). The catalyst is tailor made to work in distilled / deionized water. This first of its class, bench- and air-stable, MCAT-53TM will find wide utility in cost- effective and greener alternatives in manufacturing processes in the chemical enterprise. This catalyst that manifests its action in aqueous solutions has been developed by Chicago Discovery Solutions, USA.

Key consideration when choosing a manufacturing solvent in pharmaceutical manufacturing

253rd National Meeting (2017)

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